Optimal management of breast cancer in the elderly patient: current perspectives
Identifieur interne : 000072 ( France/Analysis ); précédent : 000071; suivant : 000073Optimal management of breast cancer in the elderly patient: current perspectives
Auteurs : Olivia Le Saux [France] ; Bertrand Ripamonti [France] ; Amandine Bruyas [France] ; Olivier Bonin [France] ; Gilles Freyer [France] ; Marc Bonnefoy [France] ; Claire Falandry [France]Source :
- Clinical Interventions in Aging [ 1176-9092 ] ; 2015.
Abstract
Breast cancer (BC) is the most common female malignancy in the world and almost one third of cases occur after 70 years of age. Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach, mainly because the elderly population is heterogeneous. In this review, we describe the various possibilities of treatment for localized or metastatic BC in an aging population. We provide an overview of the comprehensive geriatric assessment, surgery, radiotherapy, and adjuvant therapy for early localized BC and of chemotherapy and targeted therapies for metastatic BC. Finally, we attempt to put into perspective the necessary balance between the expected benefits and risks, especially in the adjuvant setting.
Url:
DOI: 10.2147/CIA.S50670
PubMed: 25609933
PubMed Central: 4293298
Affiliations:
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world and almost one third of cases occur after 70 years of age. Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach, mainly because the elderly population is heterogeneous. In this review, we describe the various possibilities of treatment for localized or metastatic BC in an aging population. We provide an overview of the comprehensive geriatric assessment, surgery, radiotherapy, and adjuvant therapy for early localized BC and of chemotherapy and targeted therapies for metastatic BC. Finally, we attempt to put into perspective the necessary balance between the expected benefits and risks, especially in the adjuvant setting.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Center, Mm" uniqKey="Center M">MM Center</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D 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Faiola</name></author><author><name sortKey="Guarrasi, R" uniqKey="Guarrasi R">R Guarrasi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mlineritsch, B" uniqKey="Mlineritsch B">B Mlineritsch</name></author><author><name sortKey="Schabel Moser, R" uniqKey="Schabel Moser R">R Schabel-Moser</name></author><author><name sortKey="Andel, J" uniqKey="Andel J">J Andel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li><li>Saint-Étienne</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Le Saux, Olivia" sort="Le Saux, Olivia" uniqKey="Le Saux O" first="Olivia" last="Le Saux">Olivia Le Saux</name></noRegion><name sortKey="Bonin, Olivier" sort="Bonin, Olivier" uniqKey="Bonin O" first="Olivier" last="Bonin">Olivier Bonin</name><name sortKey="Bonnefoy, Marc" sort="Bonnefoy, Marc" uniqKey="Bonnefoy M" first="Marc" last="Bonnefoy">Marc Bonnefoy</name><name sortKey="Bonnefoy, Marc" sort="Bonnefoy, Marc" uniqKey="Bonnefoy M" first="Marc" last="Bonnefoy">Marc Bonnefoy</name><name sortKey="Bruyas, Amandine" sort="Bruyas, Amandine" uniqKey="Bruyas A" first="Amandine" last="Bruyas">Amandine Bruyas</name><name sortKey="Bruyas, Amandine" sort="Bruyas, Amandine" uniqKey="Bruyas A" first="Amandine" last="Bruyas">Amandine Bruyas</name><name sortKey="Falandry, Claire" sort="Falandry, Claire" uniqKey="Falandry C" first="Claire" last="Falandry">Claire Falandry</name><name sortKey="Falandry, Claire" sort="Falandry, Claire" uniqKey="Falandry C" first="Claire" last="Falandry">Claire Falandry</name><name sortKey="Freyer, Gilles" sort="Freyer, Gilles" uniqKey="Freyer G" first="Gilles" last="Freyer">Gilles Freyer</name><name sortKey="Freyer, Gilles" sort="Freyer, Gilles" uniqKey="Freyer G" first="Gilles" last="Freyer">Gilles Freyer</name><name sortKey="Ripamonti, Bertrand" sort="Ripamonti, Bertrand" uniqKey="Ripamonti B" first="Bertrand" last="Ripamonti">Bertrand Ripamonti</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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